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MERIDIA
Also another study conducted in conjunction with a Knoll scientist (Dr. Timothy Seaton, medical director at Knoll) found "Small mean increases in blood pressure and pulse rate (with considerable individual variability) were observed in patients treated with sibutramine. Most of the adverse events observed on sibutramine are related to its pharmacology, including small mean increases in blood pressure and heart rate" (Bray et al, 189-98). These studies may slightly down play the increase in blood pressure and heart rate finding because these studies were associated with Knoll pharmaceuticals. However, Knoll does acknowledge this problem and addresses it through dosage adjustments.
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About Meridia
<li> A gray area exists between people who should get Meridia, and those who should not. While recommended for people with cardiovascular risk factors (due to obesity), those who have crossed the line into disease are excluded (Chase, B1). But how do you exclude people with undiagnosed heart disease? According to Dr. Michael Schwartz, an obesity researcher at the University of Washington, Seattle, "At minimum, careful history and a physical exam are required to pinpoint unacceptable risk. For some a treadmill test could help", he further states, "Among the obese with high cholesterol and hypertension, a certain percentage will have coronary heart disease and not know it. In such people, a drug which raises blood pressure and pulse could trigger angina, so anyone who experiences chest pain on Meridia should be advised to stop the drug (Chase, B1)". It seems slightly ironic because people who have hypertension and high blood pressure (due to obesity) are the ones who are most likely to want the drug, yet these are the people who are urged not to take it. </li>
<li> And now the million dollar question, "how much weight can you lose"? In the Knoll clinical studies, overweight patients on Meridia and a reduced calorie diet, in combination with lifestyle modifications, achieved an average of 5 to 10 percent weight reduction from their initial weight at various dosage levels. In one 12 month study, patients who took 10 mg of Meridia daily lost an average of 10 pounds, while those taking 15 mg daily lost an average of 14 pounds. The average weight loss in people on only a reduced calorie diet was 3.5 pounds. Study participants lost most of their weight in the first six months and maintained statistically significant weight losses for up to a year (Fentress, 33-34). Although Meridia's efficacy profile is modest, the drug's sustained actions are advantageous since obesity tends to be a chronic condition. Timothy Seaton, M.D., senior medical director at Knoll claims, "the maintained amount of weight loss is enough to reduce obesity- related health risks, including diabetes, osteoarthritis, hypertension and certain types of cancer (Portyansky, 23)". </li>
<li> In today's society the hegemonic belief surrounding weight is that thin is in and fat is out. With over half of the American population being overweight, the diet craze has swept the nation. However, a bigger player has come into the weight loss scene, the pharmaceutical industry. After the abrupt withdrawal of two anti- obesity drugs from the market in 1997, the pharmaceutical industry has been looking to fill the void in this area of the market. Meridia (sibutramine hydrochloric monohydrate), manufactured by Knoll Pharmaceutical Co, enters with caution what now appears to be a virtually deserted and uncertain anti- obesity market. The drug works to suppress appetite via serotonin (and norepinephrine) re-uptake inhibition. </li>
<li> . Also, this drug is not expected to cause heart valve damage as was observed in previous anti- obesity drugs. But it is best to be cautious about Meridia because no long term studies have been done, a least not beyond a year. Once again, this drug is for the purposes of treating obesity, therefore only people with a BMI of 30 (or 27 in the presence of other risk factors) should be taking this drug. The primary goal of this drug is not necessarily to make you look better, but to help you lose enough weight to eliminate health risks associated with obesity. People taking Meridia or considering it should also be reminded that Meridia must be used in conjunction with major lifestyle changes, such as increasing physical activity and eating right. Those who have a BMI under 30 with no risk factors are encouraged to maintain a healthy lifestyle. </li>
<li> Does Meridia Oral have any side effects? </li>
<li> What should I know before taking Meridia Oral? </li>
<li> For those who are trying to lose weight, it is often difficult to stay focused on lifestyle changes and motivated to exercise when all they can think about is food. Knoll claims that Meridia is designed to solve that problem. "Meridia helps patients comply better with an improved lifestyle", said Mayer (director of communications at Knoll), "one patient I spoke with said it felt like she had eaten a bag of popcorn, so she wasn't so hungry that all she could do was think about food". Mayer warns, "It is important for people to have realistic expectations, Meridia should be used as part of a comprehensive lifestyle management program" (Fentress, 33-34). While Meridia takes your mind of food, Knoll is stressing that it is not likely to be a magic bullet for weight problems. </li>
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BRAND NAME: Meridia
Drugs and Treatments - Meridia Oral